Which drug shows interaction with allopurinol?
What Other Drugs Interact with Allopurinol?
- azathioprine.
- benazepril.
- captopril.
- didanosine.
- dyphylline.
- enalapril.
- perindopril.
- protamine.
What drugs interact with azathioprine?
Some products that may interact with this drug are: febuxostat, past or present use of certain cancer drugs (such as cyclophosphamide, melphalan), other drugs that weaken the immune system/increase the risk of infection (such as rituximab, tofacitinib). Azathioprine is very similar to mercaptopurine.
Does azathioprine cause high uric acid?
Azathioprine significantly increased serum uric acid levels at 2 years while MMF showed non significant effect although serum creatinine was not different between both groups at the end of the study.
What should you not take with allopurinol?
Some medicines and allopurinol can interfere with each other and increase the chances of you having side effects. Tell a doctor or pharmacist if you’re taking any of these medicines before you start taking allopurinol: aspirin or medicines used to thin your blood (anticoagulants), such as warfarin. any antibiotics.
Why is allopurinol given with azathioprine?
While not commonly used together for the treatment of various chronic conditions, the concomitant use of allopurinol and azathioprine has been used to improve outcomes in pediatric and adult patients with inflammatory bowel disease, prevention of rejection in organ transplantation, and reducing thiopurine-induced …
Is allopurinol an immunosuppressant?
Abstract. Allopurinol demonstrated to have an immunosuppressive action when given at the dose of 200 microgram daily to the mice receiving skin grafts. This effect was not as apparent in adult mongrel dogs receiving kidney allografts and immediate bilateral nephrectomy.
What does allopurinol do to azathioprine?
Allopurinol interferes with the metabolism of azathioprine, increasing plasma levels of 6-mercaptopurine which may result in potentially fatal blood dyscrasias.
Can you take allopurinol with azathioprine?
Allopurinol and azathioprine should not be co-prescribed unless the combination cannot be avoided. Allopurinol interferes with the metabolism of azathioprine, increasing plasma levels of 6-mercaptopurine which may result in potentially fatal blood dyscrasias.
What is a common side effect for allopurinol?
Stomach upset, nausea, diarrhea, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
Does azathioprine cause gout?
Azathioprine, a purine analogue, significantly suppressed the purine synthesis de novo of two gouty patients manifesting overproduction of uric acid, as well as three of four gouty patients who showed normal uric acid production.
Does allopurinol inhibit TPMT?
Inhibition of TPMT by allopurinol would explain these results; however both in vitro and in vivo studies have shown a lack of inhibition of erythrocyte and human liver cytosolic TPMT activity following the addition of both allopurinol and its active metabolite, oxypurinol (alloxanthine) [29].
Can you take allopurinol and prednisone at the same time?
Interactions between your drugs No interactions were found between allopurinol and prednisone.
Which is better for gout prednisone or allopurinol?
Zyloprim (allopurinol) works well to prevent gout attacks and is cheaper than some alternatives, but it takes a few weeks to start working. Deltasone (prednisone) effectively treats a variety of conditions involving the immune system. Can help improve energy and stimulate your appetite.
What are long term side effects of allopurinol?
The more common side effects of allopurinol oral tablet can include:
- skin rash.
- diarrhea.
- nausea.
- changes in your liver function test results.
- gout flare-up (if you have gout)
Can prednisone and allopurinol be taken together?
What are the side effects of azathioprine and allopurinol?
Bone marrow suppression occurs with azathioprine-allopurinol interaction. Allopurinol inhibits the second step of metabolism, and higher 6-mercaptopurine plasma levels result, with associated toxic effects on the bone marrow and other tissues. The resulting blood dyscrasias, leucopenia, thrombocytopenia or pancytopenia, can be life threatening.
Can low-dose azathioprine and allopurinol be used together for inflammatory bowel disease?
Background: Use of azathioprine (AZA) for inflammatory bowel disease is limited by side effects or poor efficacy. Combining low-dose azathioprine with allopurinol (LDAA) bypasses side effects, improves efficacy, and may be appropriate as first-line therapy.
Is allopurinol a thiopurine inhibitor?
Allopurinol, a xanthine oxidase inhibitor used in the treatment of gout, is not infrequently coincidentally co-prescribed with the thiopurines.
Can you take 6-mercaptopurine and allopurinol together?
When co-administration is necessary, the dose of 6-mercaptopurine should be reduced and blood count monitored. When azathioprine is initiated, the prescriber should check that the patient is not taking allopurinol. The patient should be warned that azathioprine interacts with allopurinol, a treatment for gout.